Circadian Rhythms Play Role in Cancer Research

Circadian rhythms play role in cancer research.

Over the years, studies have established that circadian clocks, the internal timekeepers that run many biological processes on a near 24-hour schedule, are associated in some way with tumor growth. What's not known is precisely how the relationship works. But now researchers are uncovering some of the clock's key cancer-related components and beginning to envision a time when manipulating or ta...

Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms

Clock output pathways play a pivotal role by relaying timing information from the circadian clock to a diversity of physiological systems. Both cell-autonomous and systemic mechanisms have been implicated as clock outputs; however, the relative importance and interplay between these mechanisms are poorly understood. The cell cycle represents a highly conserved regulatory target of the circadian...

Circadian rhythms.

1997 marks the 25th anniversary of the discovery of the master circadian pacemaker in mammals in the hypothalamic suprachiasmatic nucleus. Remarkable progress has been made over the last 25 years in elucidating the physiological mechanisms involved in the entrainment, generation and expression of circadian rhythms at the cellular and systems levels. The recent discovery and cloning of the first...

Circadian rhythms.

Circadian rhythms are a ubiquitous adaptation of eukaryotic organisms to the most reliable and predictable of environmental changes, the daily cycles of light and temperature. Prominent daily rhythms in behavior, physiology, hormone levels and biochemistry (including gene expression) are not merely responses to these environmental cycles, however, but embody the organism's ability to keep and t...

Circadian rhythms in RA.